3bq7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3bq7" [edit=sysop:move=sysop])
Current revision (12:12, 30 August 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3bq7.png|left|200px]]
 
-
{{STRUCTURE_3bq7| PDB=3bq7 | SCENE= }}
+
==SAM domain of Diacylglycerol Kinase delta1 (E35G)==
 +
<StructureSection load='3bq7' size='340' side='right'caption='[[3bq7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3bq7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BQ7 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bq7 OCA], [https://pdbe.org/3bq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bq7 RCSB], [https://www.ebi.ac.uk/pdbsum/3bq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bq7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DGKD_HUMAN DGKD_HUMAN] May function as signaling molecule.<ref>PMID:17880279</ref> Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.<ref>PMID:17880279</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/3bq7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bq7 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The diacylglycerol kinase (DGK) enzymes function as regulators of intracellular signaling by altering the levels of the second messengers, diacylglycerol and phosphatidic acid. The DGK delta and eta isozymes possess a common protein-protein interaction module known as a sterile alpha-motif (SAM) domain. In DGK delta, SAM domain self-association inhibits the translocation of DGK delta to the plasma membrane. Here we show that DGK delta SAM forms a polymer and map the polymeric interface by a genetic selection for soluble mutants. A crystal structure reveals that DGKSAM forms helical polymers through a head-to-tail interaction similar to other SAM domain polymers. Disrupting polymerization by polymer interface mutations constitutively localizes DGK delta to the plasma membrane. Thus, polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. Regulation by dynamic polymerization is an emerging theme in signal transduction.
-
===SAM domain of Diacylglycerol Kinase delta1 (E35G)===
+
Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1.,Harada BT, Knight MJ, Imai S, Qiao F, Ramachander R, Sawaya MR, Gingery M, Sakane F, Bowie JU Structure. 2008 Mar;16(3):380-7. PMID:18334213<ref>PMID:18334213</ref>
-
{{ABSTRACT_PUBMED_18334213}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3bq7" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[3bq7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQ7 OCA].
+
*[[Diacylglycerol kinase 3D structures|Diacylglycerol kinase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:018334213</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Diacylglycerol kinase]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bowie, J U.]]
+
[[Category: Large Structures]]
-
[[Category: Knight, M J.]]
+
[[Category: Bowie JU]]
-
[[Category: Sawaya, M R.]]
+
[[Category: Knight MJ]]
-
[[Category: Kinase]]
+
[[Category: Sawaya MR]]
-
[[Category: Membrane]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Phorbol-ester binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Polymerization domain]]
+
-
[[Category: Sam domain]]
+
-
[[Category: Transferase]]
+
-
[[Category: Zinc-finger]]
+

Current revision

SAM domain of Diacylglycerol Kinase delta1 (E35G)

PDB ID 3bq7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bq7"
Personal tools