2zfd

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[[Image:2zfd.png|left|200px]]
 
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{{STRUCTURE_2zfd| PDB=2zfd | SCENE= }}
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==The crystal structure of plant specific calcium binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14==
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<StructureSection load='2zfd' size='340' side='right'caption='[[2zfd]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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===The crystal structure of plant specific calcium binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZFD FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18237745}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zfd OCA], [https://pdbe.org/2zfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zfd RCSB], [https://www.ebi.ac.uk/pdbsum/2zfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zfd ProSAT]</span></td></tr>
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[[2zfd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFD OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CNBL2_ARATH CNBL2_ARATH] Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Binds four calcium ions per subunit. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Mediates the inactivation of the proton pump AHA2 by CIPK11. Probably involved in regulating signaling responses to abscisic acid.<ref>PMID:17483306</ref> <ref>PMID:17898163</ref> <ref>PMID:22547024</ref>
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<ref group="xtra">PMID:018237745</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/2zfd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zfd ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Akaboshi, M.]]
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[[Category: Large Structures]]
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[[Category: Hashimoto, H.]]
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[[Category: Akaboshi M]]
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[[Category: Ishida, H.]]
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[[Category: Hashimoto H]]
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[[Category: Koizumi, N.]]
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[[Category: Ishida H]]
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[[Category: Sato, M.]]
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[[Category: Koizumi N]]
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[[Category: Shimizu, T.]]
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[[Category: Sato M]]
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[[Category: Atp-binding]]
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[[Category: Shimizu T]]
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[[Category: Calcium binding protein]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein-protein complex]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Signaling protein-transferase complex]]
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[[Category: Transferase]]
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Current revision

The crystal structure of plant specific calcium binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14

PDB ID 2zfd

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