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3a4r

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[[Image:3a4r.png|left|200px]]
 
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{{STRUCTURE_3a4r| PDB=3a4r | SCENE= }}
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==The crystal structure of SUMO-like domain 2 in Nip45==
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<StructureSection load='3a4r' size='340' side='right'caption='[[3a4r]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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===The crystal structure of SUMO-like domain 2 in Nip45===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3a4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A4R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20077568}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a4r OCA], [https://pdbe.org/3a4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a4r RCSB], [https://www.ebi.ac.uk/pdbsum/3a4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a4r ProSAT]</span></td></tr>
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[[3a4r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A4R OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/NF2IP_MOUSE NF2IP_MOUSE] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.<ref>PMID:20133688</ref> <ref>PMID:20077568</ref>
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<ref group="xtra">PMID:020077568</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/3a4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a4r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Arita, K.]]
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[[Category: Arita K]]
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[[Category: Ariyoshi, M.]]
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[[Category: Ariyoshi M]]
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[[Category: Ikeda, Y.]]
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[[Category: Ikeda Y]]
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[[Category: Saitoh, H.]]
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[[Category: Saitoh H]]
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[[Category: Sekiyama, N.]]
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[[Category: Sekiyama N]]
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[[Category: Shirakawa, M.]]
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[[Category: Shirakawa M]]
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[[Category: Tochio, H.]]
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[[Category: Tochio H]]
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[[Category: Methylation]]
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[[Category: Nucleus]]
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[[Category: Transcription]]
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[[Category: Ubiquitin fold]]
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Current revision

The crystal structure of SUMO-like domain 2 in Nip45

PDB ID 3a4r

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