1xz9
From Proteopedia
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| - | [[Image:1xz9.gif|left|200px]]<br /><applet load="1xz9" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1xz9" /> | ||
| - | '''Structure of AF-6 PDZ domain'''<br /> | ||
| - | == | + | ==Structure of AF-6 PDZ domain== |
| - | + | <StructureSection load='1xz9' size='340' side='right'caption='[[1xz9]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1xz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XZ9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xz9 OCA], [https://pdbe.org/1xz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1xz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xz9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xz/1xz9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xz9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Boisguerin | + | [[Category: Boisguerin P]] |
| - | [[Category: Joshi | + | [[Category: Joshi M]] |
| - | [[Category: Krause | + | [[Category: Krause G]] |
| - | [[Category: Leitner | + | [[Category: Leitner D]] |
| - | [[Category: Moelling | + | [[Category: Moelling K]] |
| - | [[Category: Oschkinat | + | [[Category: Oschkinat H]] |
| - | [[Category: Schade | + | [[Category: Schade M]] |
| - | [[Category: Schmieder | + | [[Category: Schmieder P]] |
| - | [[Category: Volkmer-Engert | + | [[Category: Volkmer-Engert R]] |
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Current revision
Structure of AF-6 PDZ domain
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