2wcn

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[[Image:2wcn.png|left|200px]]
 
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{{STRUCTURE_2wcn| PDB=2wcn | SCENE= }}
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==Solution structure of an LNA-modified quadruplex==
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<StructureSection load='2wcn' size='340' side='right'caption='[[2wcn]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcn OCA], [https://pdbe.org/2wcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wcn RCSB], [https://www.ebi.ac.uk/pdbsum/2wcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcn ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology.
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===SOLUTION STRUCTURE OF AN LNA-MODIFIED QUADRUPLEX===
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Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology.,Nielsen JT, Arar K, Petersen M Angew Chem Int Ed Engl. 2009;48(17):3099-103. PMID:19308940<ref>PMID:19308940</ref>
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{{ABSTRACT_PUBMED_19308940}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2wcn" style="background-color:#fffaf0;"></div>
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[[2wcn]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCN OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019308940</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Arar, K.]]
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[[Category: Large Structures]]
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[[Category: Nielsen, J T.]]
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[[Category: Sterkiella nova]]
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[[Category: Petersen, M.]]
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[[Category: Arar K]]
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[[Category: Dna]]
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[[Category: Nielsen JT]]
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[[Category: Folding topology]]
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[[Category: Petersen M]]
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[[Category: Lna]]
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[[Category: Quadruplex]]
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Current revision

Solution structure of an LNA-modified quadruplex

PDB ID 2wcn

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