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2z6e
From Proteopedia
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| - | [[Image:2z6e.png|left|200px]] | ||
| - | + | ==Crystal Structure of Human DAAM1 FH2== | |
| - | + | <StructureSection load='2z6e' size='340' side='right'caption='[[2z6e]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2z6e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z6E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6e OCA], [https://pdbe.org/2z6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z6e RCSB], [https://www.ebi.ac.uk/pdbsum/2z6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z6e ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2z6e]] is a 4 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/DAAM1_HUMAN DAAM1_HUMAN] Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.<ref>PMID:16630611</ref> <ref>PMID:17482208</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z6e_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z6e ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Fukai | + | [[Category: Large Structures]] |
| - | [[Category: Higashi | + | [[Category: Fukai S]] |
| - | [[Category: Horiuchi | + | [[Category: Higashi T]] |
| - | [[Category: Kita | + | [[Category: Horiuchi H]] |
| - | [[Category: Nureki | + | [[Category: Kita T]] |
| - | [[Category: Sato | + | [[Category: Nureki O]] |
| - | [[Category: Shirakawa | + | [[Category: Sato Y]] |
| - | [[Category: Yamashita | + | [[Category: Shirakawa R]] |
| - | + | [[Category: Yamashita M]] | |
Current revision
Crystal Structure of Human DAAM1 FH2
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Categories: Homo sapiens | Large Structures | Fukai S | Higashi T | Horiuchi H | Kita T | Nureki O | Sato Y | Shirakawa R | Yamashita M
