2raj

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[[Image:2raj.png|left|200px]]
 
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{{STRUCTURE_2raj| PDB=2raj | SCENE= }}
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==SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9==
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<StructureSection load='2raj' size='340' side='right'caption='[[2raj]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2raj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RAJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2raj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2raj OCA], [https://pdbe.org/2raj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2raj RCSB], [https://www.ebi.ac.uk/pdbsum/2raj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2raj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNX9_HUMAN SNX9_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.<ref>PMID:11799118</ref> <ref>PMID:12952949</ref> <ref>PMID:15703209</ref> <ref>PMID:17609109</ref> <ref>PMID:18388313</ref> <ref>PMID:20427313</ref> <ref>PMID:21048941</ref> <ref>PMID:17948057</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ra/2raj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2raj ConSurf].
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<div style="clear:both"></div>
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===SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9===
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==See Also==
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*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
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{{ABSTRACT_PUBMED_17948057}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2raj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAJ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017948057</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Carlsson, S R.]]
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[[Category: Large Structures]]
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[[Category: Lundmark, R.]]
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[[Category: Carlsson SR]]
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[[Category: Pylypenko, O.]]
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[[Category: Lundmark R]]
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[[Category: Rak, A.]]
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[[Category: Pylypenko O]]
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[[Category: Rasmuson, E.]]
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[[Category: Rak A]]
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[[Category: Bar domain]]
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[[Category: Rasmuson E]]
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[[Category: Membrane transport]]
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[[Category: Px domain]]
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[[Category: Sorting nexin]]
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[[Category: Structural protein]]
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[[Category: Tubulation]]
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Current revision

SO4 bound PX-BAR membrane remodeling unit of Sorting Nexin 9

PDB ID 2raj

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