This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2tys

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:24, 21 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2tys.png|left|200px]]
 
-
{{STRUCTURE_2tys| PDB=2tys | SCENE= }}
+
==CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES==
-
 
+
<StructureSection load='2tys' size='340' side='right'caption='[[2tys]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
===CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2tys]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TYS FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_9201907}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLT:[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-L-TRYPTOPHANE'>PLT</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tys OCA], [https://pdbe.org/2tys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tys RCSB], [https://www.ebi.ac.uk/pdbsum/2tys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tys ProSAT]</span></td></tr>
-
[[2tys]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TYS OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ty/2tys_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tys ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Tryptophan synthase|Tryptophan synthase]]
+
*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:009201907</ref><references group="xtra"/>
+
[[Category: Large Structures]]
-
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
+
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-
[[Category: Tryptophan synthase]]
+
[[Category: Ahmed SA]]
-
[[Category: Ahmed, S A.]]
+
[[Category: Davies DR]]
-
[[Category: Davies, D R.]]
+
[[Category: Hyde CC]]
-
[[Category: Hyde, C C.]]
+
[[Category: Miles EW]]
-
[[Category: Miles, E W.]]
+
[[Category: Parris KD]]
-
[[Category: Parris, K D.]]
+
[[Category: Rhee S]]
-
[[Category: Rhee, S.]]
+
-
[[Category: Carbon-oxygen lyase]]
+
-
[[Category: Lyase]]
+
-
[[Category: Pyridoxal phosphate]]
+
-
[[Category: Tryptophan biosynthesis]]
+

Current revision

CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES

PDB ID 2tys

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2tys"
Personal tools