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3chu

From Proteopedia

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[[Image:3chu.png|left|200px]]
 
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{{STRUCTURE_3chu| PDB=3chu | SCENE= }}
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==Crystal Structure of Di-iron Aurf==
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<StructureSection load='3chu' size='340' side='right'caption='[[3chu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal Structure of Di-iron Aurf===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3chu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CHU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18458342}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEO:MU-OXO-DIIRON'>FEO</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3chu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3chu OCA], [https://pdbe.org/3chu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3chu RCSB], [https://www.ebi.ac.uk/pdbsum/3chu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3chu ProSAT]</span></td></tr>
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[[3chu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHU OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/AURF_STRTU AURF_STRTU] Involved in the biosynthesis of the polyketide antibiotic aureothin (PubMed:14700630, PubMed:15038705). Catalyzes the oxidation of p-aminobenzoate (pABA) to p-nitrobenzoate (pNBA), an unusual polyketide synthase starter unit (PubMed:15038705, PubMed:16927313, PubMed:20798054, PubMed:18458342). Reaction mechanism involves the generation of a peroxodiiron(III/III) intermediate, which effects the initial oxidation of p-aminobenzoate to p-hydroxylaminobenzoate (Ar-NHOH) (PubMed:19731912, PubMed:20798054). Ar-NHOH is then probably directly converted to the fully oxidized p-nitrobenzoate via a four-electron N-oxidation, bypassing the formation of a nitroso compound (PubMed:20798054).<ref>PMID:14700630</ref> <ref>PMID:15038705</ref> <ref>PMID:16927313</ref> <ref>PMID:18458342</ref> <ref>PMID:19731912</ref> <ref>PMID:20798054</ref>
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<ref group="xtra">PMID:018458342</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3chu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3chu ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces thioluteus]]
[[Category: Streptomyces thioluteus]]
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[[Category: Brunzelle, J S.]]
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[[Category: Brunzelle JS]]
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[[Category: Nair, S K.]]
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[[Category: Nair SK]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Di-iron oxygenase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of Di-iron Aurf

PDB ID 3chu

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