2v1n

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[[Image:2v1n.png|left|200px]]
 
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{{STRUCTURE_2v1n| PDB=2v1n | SCENE= }}
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==SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMAN KIN17 REVEALS A WINGED HELIX FOLD==
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<StructureSection load='2v1n' size='340' side='right'caption='[[2v1n]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v1n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V1N FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ckk|2ckk]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1n OCA], [https://pdbe.org/2v1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v1n RCSB], [https://www.ebi.ac.uk/pdbsum/2v1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v1n ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v1n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v1n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human KIN17 is a 45-kDa eukaryotic DNA- and RNA-binding protein that plays an important role in nuclear metabolism and in particular in the general response to genotoxics. Its amino acids sequence contains a zinc finger motif (residues 28-50) within a 30-kDa N-terminal region conserved from yeast to human, and a 15-kDa C-terminal tandem of SH3-like subdomains (residues 268-393) only found in higher eukaryotes. Here we report the solution structure of the region 51-160 of human KIN17. We show that this fragment folds into a three-alpha-helix bundle packed against a three-stranded beta-sheet. It belongs to the winged helix (WH) family. Structural comparison with analogous WH domains reveals that KIN17 WH module presents an additional and highly conserved 3(10)-helix. Moreover, KIN17 WH helix H3 is not positively charged as in classical DNA-binding WH domains. Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix.
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===SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMAN KIN17 REVEALS A WINGED HELIX FOLD===
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Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain.,Carlier L, Couprie J, le Maire A, Guilhaudis L, Milazzo-Segalas I, Courcon M, Moutiez M, Gondry M, Davoust D, Gilquin B, Zinn-Justin S Protein Sci. 2007 Dec;16(12):2750-5. PMID:18029424<ref>PMID:18029424</ref>
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{{ABSTRACT_PUBMED_18029424}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2v1n" style="background-color:#fffaf0;"></div>
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[[2v1n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1N OCA].
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== References ==
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[[Category: Homo sapiens]]
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<references/>
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[[Category: Carlier, L.]]
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__TOC__
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[[Category: Couprie, J.]]
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</StructureSection>
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[[Category: Davoust, D.]]
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[[Category: Human]]
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[[Category: Gilquin, B.]]
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[[Category: Large Structures]]
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[[Category: Gondry, M.]]
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[[Category: Carlier, L]]
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[[Category: Guilhaudis, L.]]
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[[Category: Couprie, J]]
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[[Category: Maire, A Le.]]
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[[Category: Davoust, D]]
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[[Category: Milazzo, I.]]
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[[Category: Gilquin, B]]
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[[Category: Zinn-Justin, S.]]
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[[Category: Gondry, M]]
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[[Category: Guilhaudis, L]]
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[[Category: Maire, A Le]]
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[[Category: Milazzo, I]]
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[[Category: Zinn-Justin, S]]
[[Category: Kin17]]
[[Category: Kin17]]
[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Winged helix motif]]
[[Category: Winged helix motif]]

Current revision

SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMAN KIN17 REVEALS A WINGED HELIX FOLD

PDB ID 2v1n

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