2trc

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[[Image:2trc.png|left|200px]]
 
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{{STRUCTURE_2trc| PDB=2trc | SCENE= }}
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==PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX==
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<StructureSection load='2trc' size='340' side='right'caption='[[2trc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2trc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TRC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2trc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2trc OCA], [https://pdbe.org/2trc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2trc RCSB], [https://www.ebi.ac.uk/pdbsum/2trc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2trc ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/2trc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2trc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of transducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has been solved to 2.4 angstroms resolution. Phosducin has two domains that wrap around Gtbetagamma to form an extensive interface. The N-terminal domain binds loops on the "top" Gtbeta surface, overlapping the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha. The C-terminal domain shows structural homology to thioredoxin and binds the outer strands of Gtbeta's seventh and first blades in a manner likely to disrupt Gtbetagamma's normal orientation relative to the membrane and receptor. Phosducin's Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, toward a large flexible loop. Thus phosphorylation is not likely to affect the interface directly, but rather indirectly through an induced conformational change.
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===PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX===
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Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin.,Gaudet R, Bohm A, Sigler PB Cell. 1996 Nov 1;87(3):577-88. PMID:8898209<ref>PMID:8898209</ref>
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{{ABSTRACT_PUBMED_8898209}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2trc" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2trc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TRC OCA].
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*[[Transducin 3D structures|Transducin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008898209</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bohm, A.]]
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[[Category: Bohm A]]
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[[Category: Gaudet, R.]]
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[[Category: Gaudet R]]
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[[Category: Sigler, P B.]]
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[[Category: Sigler PB]]
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[[Category: Beta-gamma]]
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[[Category: G protein]]
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[[Category: Meka]]
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[[Category: Phosducin]]
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[[Category: Phosphorylation]]
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[[Category: Regulation]]
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[[Category: Signal transduction]]
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[[Category: Thioredoxin]]
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[[Category: Transducin]]
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[[Category: Vision]]
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Current revision

PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX

PDB ID 2trc

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