2znr
From Proteopedia
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| - | [[Image:2znr.png|left|200px]] | ||
| - | + | ==Crystal structure of the DUB domain of human AMSH-LP== | |
| - | + | <StructureSection load='2znr' size='340' side='right'caption='[[2znr]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2znr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znr OCA], [https://pdbe.org/2znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znr RCSB], [https://www.ebi.ac.uk/pdbsum/2znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znr ProSAT]</span></td></tr> |
| - | [[2znr]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/STALP_HUMAN STALP_HUMAN] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.<ref>PMID:18758443</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/2znr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2znr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Azusa | + | [[Category: Azusa Y]] |
| - | [[Category: Fukai | + | [[Category: Fukai S]] |
| - | [[Category: Iwai | + | [[Category: Iwai K]] |
| - | [[Category: Komada | + | [[Category: Komada M]] |
| - | [[Category: Mimura | + | [[Category: Mimura H]] |
| - | [[Category: Nureki | + | [[Category: Nureki O]] |
| - | [[Category: Ookata | + | [[Category: Ookata K]] |
| - | [[Category: Sato | + | [[Category: Sato Y]] |
| - | [[Category: Wang | + | [[Category: Wang X]] |
| - | [[Category: Yamagata | + | [[Category: Yamagata A]] |
| - | [[Category: Yamashita | + | [[Category: Yamashita M]] |
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Current revision
Crystal structure of the DUB domain of human AMSH-LP
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Categories: Homo sapiens | Large Structures | Azusa Y | Fukai S | Iwai K | Komada M | Mimura H | Nureki O | Ookata K | Sato Y | Wang X | Yamagata A | Yamashita M
