2vri

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[[Image:2vri.png|left|200px]]
 
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{{STRUCTURE_2vri| PDB=2vri | SCENE= }}
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==Structure of the NSP3 X-domain of human coronavirus NL63==
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<StructureSection load='2vri' size='340' side='right'caption='[[2vri]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===STRUCTURE OF THE NSP3 X-DOMAIN OF HUMAN CORONAVIRUS NL63===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_NL63 Human coronavirus NL63]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[2vri]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_coronavirus_nl63 Human coronavirus nl63]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRI OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vri OCA], [https://pdbe.org/2vri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vri RCSB], [https://www.ebi.ac.uk/pdbsum/2vri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vri ProSAT]</span></td></tr>
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[[Category: Human coronavirus nl63]]
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</table>
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[[Category: Hilgenfeld, R.]]
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== Function ==
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[[Category: Mesters, J R.]]
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[https://www.uniprot.org/uniprot/R1A_CVHNL R1A_CVHNL] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3. The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
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[[Category: Moll, R.]]
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== Evolutionary Conservation ==
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[[Category: Piotrowski, Y.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Adrp]]
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Check<jmol>
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[[Category: Atp-binding]]
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<jmolCheckbox>
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[[Category: Endonuclease]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vri_consurf.spt"</scriptWhenChecked>
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[[Category: Exonuclease]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Hcov-nl63]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Helicase]]
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</jmolCheckbox>
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[[Category: Hydrolase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vri ConSurf].
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[[Category: Macro domain]]
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<div style="clear:both"></div>
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[[Category: Membrane]]
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__TOC__
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[[Category: Metal-binding]]
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</StructureSection>
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[[Category: Nsp3]]
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[[Category: Human coronavirus NL63]]
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[[Category: Nuclease]]
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[[Category: Large Structures]]
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[[Category: Nucleotide-binding]]
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[[Category: Hilgenfeld R]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Mesters JR]]
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[[Category: Protease]]
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[[Category: Moll R]]
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[[Category: Rna replication]]
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[[Category: Piotrowski Y]]
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[[Category: Rna-binding]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Thiol protease]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Zinc-finger]]
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Current revision

Structure of the NSP3 X-domain of human coronavirus NL63

PDB ID 2vri

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