2w0t

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[[Image:2w0t.png|left|200px]]
 
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{{STRUCTURE_2w0t| PDB=2w0t | SCENE= }}
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==Solution structure of the FCS zinc finger domain of human LMBL2==
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<StructureSection load='2w0t' size='340' side='right'caption='[[2w0t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Polycomb group proteins are epigenetic regulators that maintain patterns of gene expression over multiple rounds of cell division. Many of these proteins, including polyhomeotic and the MBT repeat containing proteins SCM and dSfmbt, contain an atypical C2C2 zinc finger with a characteristic phenylalanine-cysteine-serine sequence motif. The reoccurrence of this so-called FCS zinc finger in a variety of polycomb group proteins suggests that it has an important regulatory function. We have determined the solution structure of the FCS zinc finger of the human dSfmbt homologue L(3)mbt-like 2 (L3MBTL2). The structure consists of a beta-hairpin followed by an alpha-helix. The zinc ligands are situated in the beta-hairpin and at the N-terminus of the alpha-helix an arrangement typical of the treble clef class of zinc fingers. The structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs.
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===SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2===
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Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2.,Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M Protein Sci. 2009 Mar;18(3):657-61. PMID:19241375<ref>PMID:19241375</ref>
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{{ABSTRACT_PUBMED_19241375}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2w0t" style="background-color:#fffaf0;"></div>
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[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019241375</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Allen, M D.]]
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[[Category: Large Structures]]
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[[Category: Bycroft, M.]]
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[[Category: Allen, M D]]
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[[Category: Lechtenberg, B C.]]
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[[Category: Bycroft, M]]
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[[Category: Lechtenberg, B C]]
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[[Category: Alternative splicing]]
[[Category: Chromatin regulator]]
[[Category: Chromatin regulator]]
[[Category: Lmbl2]]
[[Category: Lmbl2]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polycomb group]]
[[Category: Polycomb group]]
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[[Category: Polymorphism]]
[[Category: Rna binding]]
[[Category: Rna binding]]
[[Category: Transcription]]
[[Category: Transcription]]
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[[Category: Treble clef fold]]
[[Category: Treble clef fold]]
[[Category: Yacg]]
[[Category: Yacg]]
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[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Current revision

Solution structure of the FCS zinc finger domain of human LMBL2

PDB ID 2w0t

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