3d32

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[[Image:3d32.png|left|200px]]
 
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{{STRUCTURE_3d32| PDB=3d32 | SCENE= }}
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==Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide==
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<StructureSection load='3d32' size='340' side='right'caption='[[3d32]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3d32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D32 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d32 OCA], [https://pdbe.org/3d32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d32 RCSB], [https://www.ebi.ac.uk/pdbsum/3d32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d32 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/3d32_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d32 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
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===Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide===
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Ligand binding mode of GABAA receptor-associated protein.,Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487<ref>PMID:18638487</ref>
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{{ABSTRACT_PUBMED_18638487}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3d32" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3d32]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D32 OCA].
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*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018638487</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Stangler, T.]]
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[[Category: Large Structures]]
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[[Category: Weiergraeber, O H.]]
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[[Category: Synthetic construct]]
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[[Category: Willbold, D.]]
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[[Category: Stangler T]]
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[[Category: Alpha-beta]]
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[[Category: Weiergraeber OH]]
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[[Category: Beta-grasp fold]]
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[[Category: Willbold D]]
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[[Category: Cytoskeleton]]
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[[Category: Golgi apparatus]]
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[[Category: Membrane]]
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[[Category: Microtubule]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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Current revision

Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide

PDB ID 3d32

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