3cxn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3cxn" [edit=sysop:move=sysop])
Current revision (07:54, 9 October 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3cxn.png|left|200px]]
 
-
{{STRUCTURE_3cxn| PDB=3cxn | SCENE= }}
+
==Structure of the Urease Accessory Protein UreF from Helicobacter pylori==
 +
<StructureSection load='3cxn' size='340' side='right'caption='[[3cxn]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3cxn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxn OCA], [https://pdbe.org/3cxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxn RCSB], [https://www.ebi.ac.uk/pdbsum/3cxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UREF_HELPY UREF_HELPY] Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity).[HAMAP-Rule:MF_01385]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxn ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Urease plays a central role in the pathogenesis of Helicobacter pylori in humans. Maturation of this nickel metalloenzyme in bacteria requires the participation of the accessory proteins UreD (termed UreH in H. pylori), UreF, and UreG, which form sequential complexes with the urease apoprotein as well as UreE, a metallochaperone. Here, we describe the crystal structure of C-terminal truncated UreF from H. pylori (residues 1-233), the first UreF structure to be determined, at 1.55 A resolution using SAD methods. UreF forms a dimer in vitro and adopts an all-helical fold congruent with secondary structure prediction. On the basis of evolutionary conservation analysis, the structure reveals a probable binding surface for interaction with other urease components as well as key conserved residues of potential functional relevance. Proteins 2010. (c) 2010 Wiley-Liss, Inc.
-
===Structure of the Urease Accessory Protein UreF from Helicobacter pylori===
+
Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori.,Lam R, Romanov V, Johns K, Battaile KP, Wu-Brown J, Guthrie JL, Hausinger RP, Pai EF, Chirgadze NY Proteins. 2010 Jun 14. PMID:20635345<ref>PMID:20635345</ref>
-
{{ABSTRACT_PUBMED_20635345}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3cxn" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[3cxn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXN OCA].
+
*[[Urease accessory protein 3D structures|Urease accessory protein 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:020635345</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
-
[[Category: Chirgadze, N Y.]]
+
[[Category: Large Structures]]
-
[[Category: Dharamsi, A.]]
+
[[Category: Chirgadze NY]]
-
[[Category: Dong, A.]]
+
[[Category: Dharamsi A]]
-
[[Category: Edwards, A M.]]
+
[[Category: Dong A]]
-
[[Category: Guthrie, J.]]
+
[[Category: Edwards AM]]
-
[[Category: Johns, K.]]
+
[[Category: Guthrie J]]
-
[[Category: Lam, R.]]
+
[[Category: Johns K]]
-
[[Category: Mansoury, K.]]
+
[[Category: Lam R]]
-
[[Category: Pai, E F.]]
+
[[Category: Mansoury K]]
-
[[Category: Romanov, V.]]
+
[[Category: Pai EF]]
-
[[Category: Thambipillai, D.]]
+
[[Category: Romanov V]]
-
[[Category: Wu-Brown, J.]]
+
[[Category: Thambipillai D]]
-
[[Category: Chaperone]]
+
[[Category: Wu-Brown J]]
-
[[Category: Helical]]
+
-
[[Category: Nickel]]
+

Current revision

Structure of the Urease Accessory Protein UreF from Helicobacter pylori

PDB ID 3cxn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3cxn"
Personal tools