3bej

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[[Image:3bej.png|left|200px]]
 
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{{STRUCTURE_3bej| PDB=3bej | SCENE= }}
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==Structure of human FXR in complex with MFA-1 and co-activator peptide==
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<StructureSection load='3bej' size='340' side='right'caption='[[3bej]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bej]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MUF:(8ALPHA,10ALPHA,13ALPHA,17BETA)-17-[(4-HYDROXYPHENYL)CARBONYL]ANDROSTA-3,5-DIENE-3-CARBOXYLIC+ACID'>MUF</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bej OCA], [https://pdbe.org/3bej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bej RCSB], [https://www.ebi.ac.uk/pdbsum/3bej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bej ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bej_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bej ConSurf].
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<div style="clear:both"></div>
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===Structure of human FXR in complex with MFA-1 and co-activator peptide===
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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{{ABSTRACT_PUBMED_18391212}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3bej]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018391212</ref><references group="xtra"/>
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Becker, J W.]]
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[[Category: Large Structures]]
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[[Category: Parthasarathy, G]]
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[[Category: Becker JW]]
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[[Category: Soisson, S M.]]
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[[Category: Parthasarathy G]]
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[[Category: Activator]]
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[[Category: Soisson SM]]
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[[Category: Acyltransferase]]
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[[Category: Bar]]
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[[Category: Bile acid receptor]]
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[[Category: Dna-binding]]
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[[Category: Fxr]]
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[[Category: Metal-binding]]
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[[Category: Nhr]]
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[[Category: Nr1h4]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Transcription-transferase complex]]
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[[Category: Transferase]]
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[[Category: Zinc-finger]]
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Current revision

Structure of human FXR in complex with MFA-1 and co-activator peptide

PDB ID 3bej

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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