2y0f
From Proteopedia
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| - | [[Image:2y0f.png|left|200px]] | ||
| - | + | ==STRUCTURE OF GCPE (IspG) FROM THERMUS THERMOPHILUS HB27== | |
| + | <StructureSection load='2y0f' size='340' side='right'caption='[[2y0f]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2y0f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y0F FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y0f OCA], [https://pdbe.org/2y0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y0f RCSB], [https://www.ebi.ac.uk/pdbsum/2y0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y0f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ISPG_THET2 ISPG_THET2] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Isoprenoids are biosynthesized via the mevalonate or the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways the latter being used by most pathogenic bacteria, some parasitic protozoa, plant plastids, but not by animals. We determined the X-ray structure of the homodimeric [4Fe-4S] cluster carrying E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) of Thermus thermophilus which catalyzes the penultimate reaction of the MEP pathway and is therefore an attractive target for drug development. The [4Fe-4S] cluster ligated to three cysteines and one glutamate is encapsulated at the intersubunit interface. The substrate binding site lies in front of an (alphabeta)(8) barrel. The great [4Fe-4S] cluster-substrate distance implicates large-scale domain rearrangements during the reaction cycle. STRUCTURED SUMMARY: gcpEbinds to gcpE by x-ray crystallography (View interaction). | ||
| - | + | Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus.,Rekittke I, Nonaka T, Wiesner J, Demmer U, Warkentin E, Jomaa H, Ermler U FEBS Lett. 2010 Dec 15. PMID:21167158<ref>PMID:21167158</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2y0f" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[IspG|IspG]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: Thermus thermophilus]] | + | </StructureSection> |
| - | [[Category: Demmer | + | [[Category: Large Structures]] |
| - | [[Category: Ermler | + | [[Category: Thermus thermophilus HB27]] |
| - | [[Category: Jomaa | + | [[Category: Demmer U]] |
| - | [[Category: Nonaka | + | [[Category: Ermler U]] |
| - | [[Category: Rekittke | + | [[Category: Jomaa H]] |
| - | [[Category: Warkentin | + | [[Category: Nonaka T]] |
| - | [[Category: Wiesner | + | [[Category: Rekittke I]] |
| - | + | [[Category: Warkentin E]] | |
| - | + | [[Category: Wiesner J]] | |
| - | + | ||
Current revision
STRUCTURE OF GCPE (IspG) FROM THERMUS THERMOPHILUS HB27
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