1yb1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:56, 14 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1yb1.jpg|left|200px]]<br /><applet load="1yb1" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1yb1, resolution 1.95&Aring;" />
 
-
'''Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI'''<br />
 
-
==About this Structure==
+
==Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI==
-
1YB1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=AE2:'>AE2</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA].
+
<StructureSection load='1yb1' size='340' side='right'caption='[[1yb1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-
[[Category: Estradiol 17-beta-dehydrogenase]]
+
== Structural highlights ==
-
[[Category: Homo sapiens]]
+
<table><tr><td colspan='2'>[[1yb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YB1 FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-
[[Category: Arrowsmith, C.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOI:ANDROSTERONE'>AOI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Bray, J.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yb1 OCA], [https://pdbe.org/1yb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yb1 ProSAT]</span></td></tr>
-
[[Category: Bunkoczi, G.]]
+
</table>
-
[[Category: Delft, F Von.]]
+
== Function ==
-
[[Category: Edwards, A.]]
+
[https://www.uniprot.org/uniprot/DHB11_HUMAN DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
-
[[Category: Kavanagh, K.]]
+
== Evolutionary Conservation ==
-
[[Category: Lukacik, P.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Ng, S.]]
+
Check<jmol>
-
[[Category: Oppermann, U.]]
+
<jmolCheckbox>
-
[[Category: SGC, Structural Genomics Consortium.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1yb1_consurf.spt"</scriptWhenChecked>
-
[[Category: Sundstrom, M.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: AE2]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: CL]]
+
</jmolCheckbox>
-
[[Category: GOL]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yb1 ConSurf].
-
[[Category: SO4]]
+
<div style="clear:both"></div>
-
[[Category: human]]
+
-
[[Category: hydroxysteroid dehydrogenase]]
+
-
[[Category: sgc]]
+
-
[[Category: short chain dehydrogenase]]
+
-
[[Category: structural genomics]]
+
-
[[Category: structural genomics consortium]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:03:29 2008''
+
==See Also==
 +
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith C]]
 +
[[Category: Bray J]]
 +
[[Category: Bunkoczi G]]
 +
[[Category: Edwards A]]
 +
[[Category: Kavanagh K]]
 +
[[Category: Lukacik P]]
 +
[[Category: Ng S]]
 +
[[Category: Oppermann U]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Von Delft F]]

Current revision

Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

PDB ID 1yb1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yb1"
Personal tools