2wr8

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[[Image:2wr8.png|left|200px]]
 
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{{STRUCTURE_2wr8| PDB=2wr8 | SCENE= }}
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==Structure of Pyrococcus horikoshii SAM hydroxide adenosyltransferase in complex with SAH==
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<StructureSection load='2wr8' size='340' side='right'caption='[[2wr8]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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===STRUCTURE OF PYROCOCCUS HORIKOSHII SAM HYDROXIDE ADENOSYLTRANSFERASE IN COMPLEX WITH SAH===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WR8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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[[2wr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WR8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wr8 OCA], [https://pdbe.org/2wr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wr8 ProSAT]</span></td></tr>
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</table>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:019739191</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/RSAMH_PYRHO RSAMH_PYRHO] Catalyzes the hydrolysis of S-adenosyl-L-methionine (SAM) into adenosine and L-methionine (PubMed:18551689). Is likely stereoselective, specifically hydrolyzing (R)-S-adenosyl-L-methionine ((R)-SAM), the inactive form of the ubiquitous cofactor SAM, and not the active form of SAM, (S)-S-adenosyl-L-methionine (By similarity). Probaly plays a role in preventing accumulation of (R)-S-adenosyl-L-methionine in cells; maintenance of (S)-S-denosyl-L-methionine homochirality is important for cellular health given that the (R)-form is largely inactive as a methyl donor and can function as an inhibitor of methyltransferases (By similarity). Is unable to mediate a fluorination or chlorination reaction with SAM (PubMed:18551689).[UniProtKB:A4X4S2]<ref>PMID:18551689</ref>
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[[Category: Pyrococcus horikoshii]]
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== Evolutionary Conservation ==
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[[Category: Deng, H.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Hagan, D O.]]
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Check<jmol>
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[[Category: Johnson, K A.]]
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<jmolCheckbox>
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[[Category: Mcmahon, S A.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wr8_consurf.spt"</scriptWhenChecked>
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[[Category: Naismith, J H.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Sam]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Sn2]]
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</jmolCheckbox>
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[[Category: Transferase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wr8 ConSurf].
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[[Category: Water activation]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Deng H]]
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[[Category: Johnson KA]]
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[[Category: McMahon SA]]
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[[Category: Naismith JH]]
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[[Category: O'Hagan D]]

Current revision

Structure of Pyrococcus horikoshii SAM hydroxide adenosyltransferase in complex with SAH

PDB ID 2wr8

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