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4dx9

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[[Image:4dx9.jpg|left|200px]]
 
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{{STRUCTURE_4dx9| PDB=4dx9 | SCENE= }}
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==ICAP1 in complex with integrin beta 1 cytoplasmic tail==
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<StructureSection load='4dx9' size='340' side='right'caption='[[4dx9]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dx9]] is a 62 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DX9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dx9 OCA], [https://pdbe.org/4dx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dx9 RCSB], [https://www.ebi.ac.uk/pdbsum/4dx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dx9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ITBP1_HUMAN ITBP1_HUMAN]] Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion.[REFERENCE:8]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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KRIT1 (Krev/Rap1 Interaction Trapped-1) mutations are observed in approximately 40% of autosomal-dominant cerebral cavernous malformations (CCMs), a disease occurring in up to 0.5% of the population. We show that KRIT1 functions as a switch for beta1 integrin activation by antagonizing ICAP1 (Integrin Cytoplasmic Associated Protein-1)-mediated modulation of "inside-out" activation. We present cocrystal structures of KRIT1 with ICAP1 and ICAP1 with integrin beta1 cytoplasmic tail to 2.54 and 3.0 A resolution (the resolutions at which I/sigmaI = 2 are 2.75 and 3.0 A, respectively). We find that KRIT1 binds ICAP1 by a bidentate surface, that KRIT1 directly competes with integrin beta1 to bind ICAP1, and that KRIT1 antagonizes ICAP1-modulated integrin activation using this site. We also find that KRIT1 contains an N-terminal Nudix domain, in a region previously designated as unstructured. We therefore provide insights to integrin regulation and CCM-associated KRIT1 function.
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===ICAP1 in complex with integrin beta 1 cytoplasmic tail===
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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.,Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ Mol Cell. 2013 Jan 9. pii: S1097-2765(12)01014-3. doi:, 10.1016/j.molcel.2012.12.005. PMID:23317506<ref>PMID:23317506</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[4dx9]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX9 OCA].
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<div class="pdbe-citations 4dx9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boggon, T J.]]
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[[Category: Large Structures]]
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[[Category: Calderwood, D A.]]
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[[Category: Boggon TJ]]
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[[Category: Draheim, K.]]
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[[Category: Calderwood DA]]
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[[Category: Liu, W.]]
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[[Category: Draheim K]]
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[[Category: Zhang, R.]]
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[[Category: Liu W]]
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[[Category: Integrin beta-1]]
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[[Category: Zhang R]]
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[[Category: Integrin binding]]
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[[Category: Membrane]]
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[[Category: Protein binding]]
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[[Category: Protein-protien complex]]
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[[Category: Ptb domain]]
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Current revision

ICAP1 in complex with integrin beta 1 cytoplasmic tail

PDB ID 4dx9

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