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3p3k

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[[Image:3p3k.png|left|200px]]
 
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{{STRUCTURE_3p3k| PDB=3p3k | SCENE= }}
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==The crystal structure of translationally controlled tumor protein (TCTP) of Plasmodium falciparum==
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<StructureSection load='3p3k' size='340' side='right'caption='[[3p3k]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3k OCA], [https://pdbe.org/3p3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3k RCSB], [https://www.ebi.ac.uk/pdbsum/3p3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TCTP_PLAF7 TCTP_PLAF7] Involved in calcium binding and microtubule stabilization.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor protein of Plasmodium falciparum (PfTCTP) with the anti-malarial drug artemisinin. Furthermore, we investigated the crystal structure of PfTCTP. Using mass spectrometry, bioinformatic approaches and surface plasmon resonance spectroscopy, we identified novel binding sites of artemisinin which are in direct neighborhood to amino acids 19-46, 108-134 and 140-163. The regions covered by these residues are known to be functionally important for TCTP function. We conclude that interaction of artemisinin with TCTP may be at least in part explain the antimalarial activity of artemisinin.
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===The crystal structure of translationally controlled tumor protein (TCTP) of Plasmodium falciparum===
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Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.,Eichhorn T, Winter D, Buchele B, Dirdjaja N, Frank M, Lehmann WD, Mertens R, Krauth-Siegel RL, Simmet T, Granzin J, Efferth T Biochem Pharmacol. 2012 Oct 17. pii: S0006-2952(12)00678-8. doi:, 10.1016/j.bcp.2012.10.006. PMID:23085438<ref>PMID:23085438</ref>
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{{ABSTRACT_PUBMED_23085438}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3p3k" style="background-color:#fffaf0;"></div>
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[[3p3k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3K OCA].
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== References ==
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[[Category: Plasmodium falciparum 3d7]]
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<references/>
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[[Category: Dirdjaja, N.]]
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__TOC__
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[[Category: Efferth, T.]]
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</StructureSection>
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[[Category: Eichhorn, T.]]
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[[Category: Large Structures]]
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[[Category: Frank, M.]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Granzin, J.]]
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[[Category: Dirdjaja N]]
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[[Category: Krauth-Siegel, L.]]
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[[Category: Efferth T]]
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[[Category: Winter, D.]]
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[[Category: Eichhorn T]]
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[[Category: Mainly beta]]
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[[Category: Frank M]]
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[[Category: Metal binding protein]]
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[[Category: Granzin J]]
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[[Category: Krauth-Siegel L]]
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[[Category: Winter D]]

Current revision

The crystal structure of translationally controlled tumor protein (TCTP) of Plasmodium falciparum

PDB ID 3p3k

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