3tjy

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[[Image:3tjy.png|left|200px]]
 
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{{STRUCTURE_3tjy| PDB=3tjy | SCENE= }}
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==Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion==
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<StructureSection load='3tjy' size='340' side='right'caption='[[3tjy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._maculicola_str._ES4326 Pseudomonas syringae pv. maculicola str. ES4326]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjy OCA], [https://pdbe.org/3tjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjy RCSB], [https://www.ebi.ac.uk/pdbsum/3tjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPAB3_PSEYM HPAB3_PSEYM] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, promotes virulence, in part, by enhancing the development of disease symptoms and bacterial growth.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL contains two structurally homologous yet functionally distinct domains. The N-terminal domain corresponds to the previously described Pto-binding domain, while the previously uncharacterised C-terminal domain spans residues 308-385. While structurally similar, these domains do not share significant sequence similarity and most importantly demonstrate significant differences in key residues involved in host protein recognition, suggesting that each of them targets a different host protein.
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===Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion===
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Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors.,Singer AU, Wu B, Yee A, Houliston S, Xu X, Cui H, Skarina T, Garcia M, Semesi A, Arrowsmith CH, Savchenko A Biochemistry. 2012 Jan 10;51(1):1-3. Epub 2011 Dec 28. PMID:22191472<ref>PMID:22191472</ref>
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{{ABSTRACT_PUBMED_22191472}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tjy" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3tjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._maculicola_str._es4326 Pseudomonas syringae pv. maculicola str. es4326]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJY OCA].
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*[[Avirulence protein 3D structures|Avirulence protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022191472</ref><references group="xtra"/>
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__TOC__
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[[Category: Pseudomonas syringae pv. maculicola str. es4326]]
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</StructureSection>
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[[Category: Cui, H.]]
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[[Category: Large Structures]]
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[[Category: Edwards, A M.]]
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[[Category: Pseudomonas syringae pv. maculicola str. ES4326]]
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[[Category: Joachimiak, A.]]
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[[Category: Cui H]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Edwards AM]]
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[[Category: Savchenko, A.]]
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[[Category: Joachimiak A]]
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[[Category: Singer, A U.]]
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[[Category: Savchenko A]]
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[[Category: Stein, A.]]
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[[Category: Singer AU]]
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[[Category: Xu, X.]]
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[[Category: Stein A]]
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[[Category: Helical bundle]]
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[[Category: Xu X]]
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[[Category: Hoppmal]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Pseudomonas syringae]]
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[[Category: Psi-biology]]
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[[Category: Pto]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Type iii effector]]
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Current revision

Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion

PDB ID 3tjy

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