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4dia
From Proteopedia
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| - | [[Image:4dia.png|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE OF THE D248N mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 4.6== | |
| - | + | <StructureSection load='4dia' size='340' side='right'caption='[[4dia]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4dia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4d9d 4d9d]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DIA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dia OCA], [https://pdbe.org/4dia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dia RCSB], [https://www.ebi.ac.uk/pdbsum/4dia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dia ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[4dia]] is a 1 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/LIGI_SPHSK LIGI_SPHSK] Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway (PubMed:9864312). Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA) (PubMed:29658701, PubMed:22475079). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions (PubMed:22475079). Also catalyzes the reverse reaction (PubMed:22475079, PubMed:9864312). Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate (PubMed:9864312).<ref>PMID:22475079</ref> <ref>PMID:29658701</ref> <ref>PMID:9864312</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sphingomonas paucimobilis]] | [[Category: Sphingomonas paucimobilis]] | ||
| - | [[Category: Almo | + | [[Category: Almo SC]] |
| - | [[Category: Hobbs | + | [[Category: Hobbs ME]] |
| - | [[Category: Malashkevich | + | [[Category: Malashkevich VN]] |
| - | [[Category: Raushel | + | [[Category: Raushel FM]] |
| - | [[Category: Toro | + | [[Category: Toro R]] |
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF THE D248N mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 4.6
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