3ed3

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[[Image:3ed3.png|left|200px]]
 
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{{STRUCTURE_3ed3| PDB=3ed3 | SCENE= }}
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==Crystal Structure of the Yeast Dithiol/Disulfide Oxidoreductase Mpd1p==
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<StructureSection load='3ed3' size='340' side='right'caption='[[3ed3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ed3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ED3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ED3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ed3 OCA], [https://pdbe.org/3ed3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ed3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ed3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ed3 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3ed3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ed3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Oxidoreductases belonging to the protein disulfide isomerase (PDI) family promote proper disulfide bond formation in substrate proteins in the endoplasmic reticulum. In plants and metazoans, new family members continue to be identified and assigned to various functional niches. PDI-like proteins typically contain tandem thioredoxin-fold domains. The limited information available suggested that the relative orientations of these domains may be quite uniform across the family, and structural models based on this assumption are appearing. However, the X-ray crystal structure of the yeast PDI family protein Mpd1p, described here, demonstrates the radically different domain orientations and surface properties achievable with multiple copies of the thioredoxin fold. A comparison of Mpd1p with yeast Pdi1p expands our perspective on the contexts in which redox-active motifs are presented in the PDI family.
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===Crystal Structure of the Yeast Dithiol/Disulfide Oxidoreductase Mpd1p===
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Yeast Mpd1p reveals the structural diversity of the protein disulfide isomerase family.,Vitu E, Gross E, Greenblatt HM, Sevier CS, Kaiser CA, Fass D J Mol Biol. 2008 Dec 19;384(3):631-40. Epub 2008 Sep 27. PMID:18845159<ref>PMID:18845159</ref>
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{{ABSTRACT_PUBMED_18845159}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3ed3" style="background-color:#fffaf0;"></div>
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[[3ed3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ED3 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018845159</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Protein disulfide-isomerase]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Fass, D.]]
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[[Category: Fass D]]
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[[Category: Greenblatt, H M.]]
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[[Category: Greenblatt HM]]
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[[Category: Vitu, E.]]
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[[Category: Vitu E]]
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[[Category: Cxxc]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Isomerase]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin-like domain]]
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Current revision

Crystal Structure of the Yeast Dithiol/Disulfide Oxidoreductase Mpd1p

PDB ID 3ed3

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