3e6y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3e6y" [edit=sysop:move=sysop])
Current revision (05:46, 17 October 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3e6y.png|left|200px]]
 
-
{{STRUCTURE_3e6y| PDB=3e6y | SCENE= }}
+
==Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A==
 +
<StructureSection load='3e6y' size='340' side='right'caption='[[3e6y]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3e6y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_plumbaginifolia Nicotiana plumbaginifolia] and [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E6Y FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CW1:COTYLENIN+A'>CW1</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6y OCA], [https://pdbe.org/3e6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e6y RCSB], [https://www.ebi.ac.uk/pdbsum/3e6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e6y ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/1433C_TOBAC 1433C_TOBAC]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e6y_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e6y ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Cotylenin A, a fungal metabolite originally described as a cytokinin-like bioactive substance against plants shows differentiation-inducing and anti-tumor activity in certain human cancers. Here, we present the crystal structure of cotylenin A acting on a 14-3-3 regulatory protein complex. By comparison with the closely related, but non-anticancer agent fusicoccin A, a rationale for the activity of cotylenin A in human cancers is presented. This class of fusicoccane diterpenoids are possible general modulators of 14-3-3 protein-protein interactions. In this regard, specificities for individual 14-3-3/target protein complexes might be achieved by varying the substituent pattern of the diterpene ring system. As the different activities of fusicoccin A and cotylenin A in human cancers suggest, hydroxylation of C12 might be a sufficient determinant of structural specificity.
-
===Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A===
+
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A.,Ottmann C, Weyand M, Sassa T, Inoue T, Kato N, Wittinghofer A, Oecking C J Mol Biol. 2009 Mar 6;386(4):913-9. PMID:19244612<ref>PMID:19244612</ref>
-
{{ABSTRACT_PUBMED_19244612}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3e6y" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[3e6y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6Y OCA].
+
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:019244612</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Nicotiana plumbaginifolia]]
[[Category: Nicotiana tabacum]]
[[Category: Nicotiana tabacum]]
-
[[Category: Oecking, C.]]
+
[[Category: Oecking C]]
-
[[Category: Ottmann, C.]]
+
[[Category: Ottmann C]]
-
[[Category: Weyand, M.]]
+
[[Category: Weyand M]]
-
[[Category: Wittinghofer, A.]]
+
[[Category: Wittinghofer A]]
-
[[Category: Adapter protein]]
+
-
[[Category: Signaling protein]]
+

Current revision

Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A

PDB ID 3e6y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3e6y"
Personal tools