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| - | [[Image:1yl2.jpg|left|200px]]<br /><applet load="1yl2" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[2ca7]] This PDB entry is obsolete and replaced by 2ca7 |
| - | caption="1yl2" />
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| - | '''Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family- Structural and functional characterization'''<br />
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| - | ==Overview==
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| - | Conkunitzin-S1 (Conk-S1) is a 60-residue neurotoxin from the venom of the cone snail Conus striatus that interacts with voltage-gated potassium channels. Conk-S1 shares sequence homology with Kunitz-type proteins but contains only two out of the three highly conserved cysteine bridges, which are typically found in these small, basic protein modules. In this study the three-dimensional structure of Conk-S1 has been solved by multidimensional NMR spectroscopy. The solution structure of recombinant Conk-S1 shows that a Kunitz fold is present, even though one of the highly conserved disulfide cross-links is missing. Introduction of a third, homologous disulfide bond into Conk-S1 results in a functional toxin with similar affinity for Shaker potassium channels. The affinity of Conk-S1 can be enhanced by a pore mutation within the Shaker channel pore indicating an interaction of Conk-S1 with the vestibule of potassium channels.
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| - | ==About this Structure==
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| - | 1YL2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YL2 OCA].
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| - | ==Reference==
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| - | Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization., Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S, J Biol Chem. 2005 Jun 24;280(25):23766-70. Epub 2005 Apr 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15833744 15833744]
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| - | [[Category: Conus striatus]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Bayrhuber, M.]]
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| - | [[Category: Becker, S.]]
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| - | [[Category: Ferber, M.]]
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| - | [[Category: Graf, R.]]
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| - | [[Category: Korukottu, J.]]
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| - | [[Category: Olivera, B M.]]
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| - | [[Category: Terlau, H.]]
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| - | [[Category: Vijayan, V.]]
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| - | [[Category: Zweckstetter, M.]]
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| - | [[Category: neurotoxin; kunitz-domain; potassium channel blocker]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:28 2008''
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