3e4d

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[[Image:3e4d.png|left|200px]]
 
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{{STRUCTURE_3e4d| PDB=3e4d | SCENE= }}
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==Structural and Kinetic Study of an S-Formylglutathione Hydrolase from Agrobacterium tumefaciens==
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<StructureSection load='3e4d' size='340' side='right'caption='[[3e4d]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e4d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4d OCA], [https://pdbe.org/3e4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4d RCSB], [https://www.ebi.ac.uk/pdbsum/3e4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A9CJ11_AGRFC A9CJ11_AGRFC] Serine hydrolase involved in the detoxification of formaldehyde.[RuleBase:RU363068]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/3e4d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e4d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the Atu1476 protein from Agrobacterium tumefaciens was determined at 2 A resolution. The crystal structure and biochemical characterization of this enzyme support the conclusion that this protein is an S-formylglutathione hydrolase (AtuSFGH). The three dimensional structure of AtuSFGH contains the alpha/beta hydrolase fold topology and exists as a homo-dimer. Contacts between the two monomers in the dimer are formed both by hydrogen bonds and salt bridges. Biochemical characterization reveals that AtuSFGH hydrolyzes C-O bonds with high affinity towards short to medium chain esters, unlike the other known SFGHs which have greater affinity towards shorter chained esters. A potential role for Cys54 in regulation of enzyme activity through S-glutathionylation is also proposed.
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===Structural and Kinetic Study of an S-Formylglutathione Hydrolase from Agrobacterium tumefaciens===
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The structure of a putative S-formylglutathione hydrolase from agrobacterium tumefaciens.,van Straaten KE, Gonzalez CF, Valladares RB, Xu X, Savchenko AV, Sanders DA Protein Sci. 2009 Aug 3. PMID:19653299<ref>PMID:19653299</ref>
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{{ABSTRACT_PUBMED_19653299}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3e4d" style="background-color:#fffaf0;"></div>
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[[3e4d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4D OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019653299</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Agrobacterium tumefaciens]]
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[[Category: Agrobacterium fabrum str. C58]]
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[[Category: Gonzalez, C F.]]
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[[Category: Large Structures]]
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[[Category: Sanders, D A.R.]]
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[[Category: Gonzalez CF]]
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[[Category: Savchenko, A V.]]
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[[Category: Sanders DAR]]
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[[Category: Straaten, K E.Van.]]
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[[Category: Savchenko AV]]
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[[Category: Valladares, R B.]]
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[[Category: Valladares RB]]
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[[Category: Xu, X.]]
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[[Category: Van Straaten KE]]
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[[Category: Catalytic triad]]
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[[Category: Xu X]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase fold family]]
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[[Category: Kinetic]]
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[[Category: Proposed reaction mechanism]]
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[[Category: S-formylglutathione hydrolase]]
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Current revision

Structural and Kinetic Study of an S-Formylglutathione Hydrolase from Agrobacterium tumefaciens

PDB ID 3e4d

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