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3ea2

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[[Image:3ea2.png|left|200px]]
 
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{{STRUCTURE_3ea2| PDB=3ea2 | SCENE= }}
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==Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis==
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<StructureSection load='3ea2' size='340' side='right'caption='[[3ea2]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ea2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EA2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ea2 OCA], [https://pdbe.org/3ea2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ea2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ea2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ea2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLC_BACTU PLC_BACTU] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3ea2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ea2 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis===
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==See Also==
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*[[Phospholipase C|Phospholipase C]]
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{{ABSTRACT_PUBMED_19369255}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3ea2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EA2 OCA].
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==Reference==
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<ref group="xtra">PMID:019369255</ref><references group="xtra"/>
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[[Category: Bacillus thuringiensis]]
[[Category: Bacillus thuringiensis]]
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[[Category: Phosphatidylinositol diacylglycerol-lyase]]
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[[Category: Large Structures]]
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[[Category: Head, J F.]]
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[[Category: Head JF]]
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[[Category: Redfied, A G.]]
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[[Category: Redfied AG]]
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[[Category: Roberts, M F.]]
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[[Category: Roberts MF]]
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[[Category: Seaton, B A.]]
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[[Category: Seaton BA]]
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[[Category: Shao, C.]]
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[[Category: Shao C]]
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[[Category: Shi, X.]]
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[[Category: Shi X]]
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[[Category: Zambonelli, C.]]
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[[Category: Zambonelli C]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Dimer]]
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[[Category: Interfacially impaired]]
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[[Category: Lipid degradation]]
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[[Category: Lyase]]
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[[Category: Membrane binding]]
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[[Category: Myo-inositol]]
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[[Category: Phosphatidylinositol-specific phospholipase c]]
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[[Category: Pi-plc]]
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[[Category: Secreted]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis

PDB ID 3ea2

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