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| - | [[Image:1ymf.gif|left|200px]]<br /><applet load="1ymf" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[5ffm]] This PDB entry is obsolete and replaced by 5ffm |
| - | caption="1ymf, resolution 2.6Å" />
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| - | '''crystal structure of yellow fever virus NS3 helicase complexed with ADP'''<br />
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| - | ==Overview==
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| - | Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.
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| - | ==About this Structure==
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| - | 1YMF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus] with <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMF OCA].
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| - | ==Reference==
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| - | Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16051820 16051820]
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| - | [[Category: Single protein]]
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| - | [[Category: Yellow fever virus]]
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| - | [[Category: Bera, A K.]]
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| - | [[Category: Kuhn, R J.]]
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| - | [[Category: Smith, J L.]]
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| - | [[Category: Wu, J.]]
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| - | [[Category: ADP]]
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| - | [[Category: adp]]
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| - | [[Category: atpase]]
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| - | [[Category: complex]]
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| - | [[Category: dead-box]]
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| - | [[Category: flavivirus]]
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| - | [[Category: helicase]]
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| - | [[Category: rtpase]]
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| - | [[Category: yellow fever virus]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:48 2008''
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Current revision
- REDIRECT 5ffm This PDB entry is obsolete and replaced by 5ffm
