3w4k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of human DAAO in complex with coumpound 13== | |
| + | <StructureSection load='3w4k' size='340' side='right'caption='[[3w4k]], [[Resolution|resolution]] 2.86Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3w4k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W4K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3LD:3-HYDROXY-6-(2-PHENYLETHYL)PYRIDAZIN-4(1H)-ONE'>3LD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w4k OCA], [https://pdbe.org/3w4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w4k RCSB], [https://www.ebi.ac.uk/pdbsum/3w4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w4k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hamajima T]] | ||
| + | [[Category: Harada K]] | ||
| + | [[Category: Hondo T]] | ||
| + | [[Category: Matsumoto Y]] | ||
| + | [[Category: Nakanishi K]] | ||
| + | [[Category: Namatame I]] | ||
| + | [[Category: Niimi T]] | ||
| + | [[Category: Orita M]] | ||
| + | [[Category: Sakashita H]] | ||
| + | [[Category: Takeuchi M]] | ||
| + | [[Category: Warizaya M]] | ||
| + | [[Category: Watanabe T]] | ||
| + | [[Category: Yamaguchi T]] | ||
Current revision
Crystal Structure of human DAAO in complex with coumpound 13
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Categories: Homo sapiens | Large Structures | Hamajima T | Harada K | Hondo T | Matsumoto Y | Nakanishi K | Namatame I | Niimi T | Orita M | Sakashita H | Takeuchi M | Warizaya M | Watanabe T | Yamaguchi T
