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4hl4

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[[Image:4hl4.jpg|left|200px]]
 
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{{STRUCTURE_4hl4| PDB=4hl4 | SCENE= }}
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==Crystal structure of the human TBC1D20 RabGAP domain==
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<StructureSection load='4hl4' size='340' side='right'caption='[[4hl4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of the human TBC1D20 RabGAP domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hl4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HL4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23236136}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl4 OCA], [https://pdbe.org/4hl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hl4 RCSB], [https://www.ebi.ac.uk/pdbsum/4hl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl4 ProSAT]</span></td></tr>
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[[4hl4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL4 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TBC20_HUMAN TBC20_HUMAN] Micro syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TBC20_HUMAN TBC20_HUMAN] GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gavriljuk, K.]]
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[[Category: Large Structures]]
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[[Category: Gazdag, E M.]]
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[[Category: Gavriljuk K]]
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[[Category: Gerwert, K.]]
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[[Category: Gazdag EM]]
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[[Category: Goody, R S.]]
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[[Category: Gerwert K]]
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[[Category: Itzen, A.]]
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[[Category: Goody RS]]
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[[Category: Koetting, C.]]
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[[Category: Itzen A]]
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[[Category: Catalytic domain]]
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[[Category: Koetting C]]
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[[Category: Fluoride]]
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[[Category: Gtp hydrolase]]
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[[Category: Gtpase-activating protein]]
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[[Category: Hydrolase activator]]
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[[Category: Rab gtp-binding protein]]
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[[Category: Rab1b]]
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[[Category: Rabgap]]
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[[Category: Tbc]]
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Current revision

Crystal structure of the human TBC1D20 RabGAP domain

PDB ID 4hl4

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