4gxk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:58, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4gxk.jpg|left|200px]]
 
-
{{STRUCTURE_4gxk| PDB=4gxk | SCENE= }}
+
==R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog==
 +
<StructureSection load='4gxk' size='340' side='right'caption='[[4gxk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4gxk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXK FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.998&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=F2A:2-DEOXY-5-O-[(S)-HYDROXY{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]METHYL}PHOSPHORYL]ADENOSINE'>F2A</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxk OCA], [https://pdbe.org/4gxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxk RCSB], [https://www.ebi.ac.uk/pdbsum/4gxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
-
===R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog===
+
==See Also==
-
 
+
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
-
{{ABSTRACT_PUBMED_23267011}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[4gxk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXK OCA].
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Beard, W A.]]
+
[[Category: Large Structures]]
-
[[Category: Freudenthal, B D.]]
+
[[Category: Synthetic construct]]
-
[[Category: Wilson, S H.]]
+
[[Category: Beard WA]]
-
[[Category: Lyase/dna polymerase]]
+
[[Category: Freudenthal BD]]
-
[[Category: Transferase]]
+
[[Category: Wilson SH]]
-
[[Category: Transferase-dna complex]]
+

Current revision

R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog

PDB ID 4gxk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4gxk"
Personal tools