4gra

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[[Image:4gra.jpg|left|200px]]
 
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{{STRUCTURE_4gra| PDB=4gra | SCENE= }}
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==Crystal structure of SULT1A1 bound with PAP==
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<StructureSection load='4gra' size='340' side='right'caption='[[4gra]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gra OCA], [https://pdbe.org/4gra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gra RCSB], [https://www.ebi.ac.uk/pdbsum/4gra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gra ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1A1_HUMAN ST1A1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.<ref>PMID:12471039</ref> <ref>PMID:16221673</ref>
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===Crystal structure of SULT1A1 bound with PAP===
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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{{ABSTRACT_PUBMED_23256751}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4gra]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRA OCA].
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</StructureSection>
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[[Category: Aryl sulfotransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Cook, I.]]
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[[Category: Almo SC]]
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[[Category: Falany, C N.]]
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[[Category: Cook I]]
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[[Category: Kim, J.]]
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[[Category: Falany CN]]
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[[Category: Leyh, T S.]]
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[[Category: Kim J]]
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[[Category: Wang, T.]]
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[[Category: Leyh TS]]
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[[Category: Estradiol]]
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[[Category: Wang T]]
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[[Category: Hormone regulation]]
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[[Category: Sulfotransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of SULT1A1 bound with PAP

PDB ID 4gra

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