2lr1

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[[Image:2lr1.png|left|200px]]
 
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{{STRUCTURE_2lr1| PDB=2lr1 | SCENE= }}
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==Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA==
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<StructureSection load='2lr1' size='340' side='right'caption='[[2lr1]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lr1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr1 OCA], [https://pdbe.org/2lr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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===Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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{{ABSTRACT_PUBMED_23213219}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2lr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR1 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ma, J.]]
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[[Category: Human herpesvirus 5 strain AD169]]
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[[Category: Apoptosis-signaling protein complex]]
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[[Category: Large Structures]]
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[[Category: Ma J]]

Current revision

Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA

PDB ID 2lr1

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