3jue

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[[Image:3jue.png|left|200px]]
 
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{{STRUCTURE_3jue| PDB=3jue | SCENE= }}
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==Crystal Structure of ArfGAP and ANK repeat domain of ACAP1==
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<StructureSection load='3jue' size='340' side='right'caption='[[3jue]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal Structure of ArfGAP and ANK repeat domain of ACAP1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jue]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22645133}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jue OCA], [https://pdbe.org/3jue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jue RCSB], [https://www.ebi.ac.uk/pdbsum/3jue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jue ProSAT]</span></td></tr>
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[[3jue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUE OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/ACAP1_HUMAN ACAP1_HUMAN] GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.<ref>PMID:11062263</ref> <ref>PMID:16256741</ref> <ref>PMID:17398097</ref> <ref>PMID:17664335</ref> <ref>PMID:22645133</ref>
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<ref group="xtra">PMID:022645133</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3jue_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jue ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ma, J.]]
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[[Category: Large Structures]]
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[[Category: Pang, X.]]
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[[Category: Ma J]]
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[[Category: Sun, F.]]
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[[Category: Pang X]]
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[[Category: Zhang, K.]]
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[[Category: Sun F]]
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[[Category: Zhou, Q.]]
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[[Category: Zhang K]]
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[[Category: Ank repeat]]
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[[Category: Zhou Q]]
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[[Category: Arfgap domain]]
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[[Category: Gtpase activation]]
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[[Category: Metal-binding]]
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[[Category: Nitration]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Protein transport-endocytosis complex]]
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[[Category: Transport]]
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[[Category: Zinc-binding module]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of ArfGAP and ANK repeat domain of ACAP1

PDB ID 3jue

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