1yrk

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[[Image:1yrk.gif|left|200px]]<br /><applet load="1yrk" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1yrk, resolution 1.70&Aring;" />
 
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'''The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain'''<br />
 
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==Overview==
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==The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain==
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<StructureSection load='1yrk' size='340' side='right'caption='[[1yrk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yrk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YRK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrk OCA], [https://pdbe.org/1yrk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yrk RCSB], [https://www.ebi.ac.uk/pdbsum/1yrk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yrk ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/1yrk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yrk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
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==About this Structure==
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C2 can do it, too.,Sondermann H, Kuriyan J Cell. 2005 Apr 22;121(2):158-60. PMID:15851022<ref>PMID:15851022</ref>
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1YRK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15851022 15851022]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1yrk" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Benes, C H.]]
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[[Category: Cantley, L C.]]
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[[Category: Dharia, T.]]
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[[Category: Elia, A E.]]
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[[Category: Soltoff, S P.]]
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[[Category: Wu, N.]]
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[[Category: ACY]]
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[[Category: c2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:08:20 2008''
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==See Also==
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*[[Protein kinase C 3D structures|Protein kinase C 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Benes CH]]
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[[Category: Cantley LC]]
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[[Category: Dharia T]]
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[[Category: Elia AE]]
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[[Category: Soltoff SP]]
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[[Category: Wu N]]

Current revision

The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain

PDB ID 1yrk

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