4ig8

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[[Image:4ig8.jpg|left|200px]]
 
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{{STRUCTURE_4ig8| PDB=4ig8 | SCENE= }}
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==Structural basis for cytosolic double-stranded RNA surveillance by human OAS1==
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<StructureSection load='4ig8' size='340' side='right'caption='[[4ig8]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Structural basis for cytosolic double-stranded RNA surveillance by human OAS1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ig8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IG8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[4ig8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IG8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ig8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ig8 OCA], [https://pdbe.org/4ig8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ig8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ig8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ig8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OAS1_HUMAN OAS1_HUMAN] Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.<ref>PMID:12799444</ref> <ref>PMID:18931074</ref> <ref>PMID:19923450</ref> <ref>PMID:23319625</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Donovan, J.]]
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[[Category: Large Structures]]
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[[Category: Korennykh, A.]]
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[[Category: Donovan J]]
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[[Category: Cytosol]]
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[[Category: Korennykh A]]
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[[Category: Double-stranded rna]]
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[[Category: Innate immune system double-stranded dsrna sensor rna polymerase]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Nucleotidyl transferase 2-5a synthetase]]
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[[Category: Rnase l activator]]
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[[Category: Transferase-rna complex]]
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Current revision

Structural basis for cytosolic double-stranded RNA surveillance by human OAS1

PDB ID 4ig8

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