4gqs
From Proteopedia
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| - | [[Image:4gqs.png|left|200px]] | ||
| - | + | ==Structure of Human Microsomal Cytochrome P450 (CYP) 2C19== | |
| + | <StructureSection load='4gqs' size='340' side='right'caption='[[4gqs]], [[Resolution|resolution]] 2.87Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.87Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XV:(4-HYDROXY-3,5-DIMETHYLPHENYL)(2-METHYL-1-BENZOFURAN-3-YL)METHANONE'>0XV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqs OCA], [https://pdbe.org/4gqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gqs RCSB], [https://www.ebi.ac.uk/pdbsum/4gqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gqs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Resistance to clopidogrel;Antidepressant or antipsychotics toxicity or dose selection;Voriconazole toxicity. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP2CJ_HUMAN CP2CJ_HUMAN] Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. | ||
| - | == | + | ==See Also== |
| - | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[ | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Johnson EF]] |
| - | [[Category: | + | [[Category: Reynald RL]] |
| - | [[Category: | + | [[Category: Sansen S]] |
| - | [[Category: | + | [[Category: Stout CD]] |
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Current revision
Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
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