1tpz

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[[Image:1tpz.png|left|200px]]
 
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{{STRUCTURE_1tpz| PDB=1tpz | SCENE= }}
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==Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases==
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<StructureSection load='1tpz' size='340' side='right'caption='[[1tpz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tpz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15350217}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpz OCA], [https://pdbe.org/1tpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpz RCSB], [https://www.ebi.ac.uk/pdbsum/1tpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpz ProSAT]</span></td></tr>
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[[1tpz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPZ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
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<ref group="xtra">PMID:015350217</ref><ref group="xtra">PMID:012732635</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ghosh, A.]]
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[[Category: Ghosh A]]
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[[Category: Herrmann, C.]]
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[[Category: Herrmann C]]
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[[Category: Howard, J.]]
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[[Category: Howard J]]
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[[Category: Uthaiah, R.]]
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[[Category: Uthaiah R]]
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[[Category: Wolf, E.]]
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[[Category: Wolf E]]
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[[Category: Dimer]]
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[[Category: Gtpase]]
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[[Category: Immunology]]
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[[Category: Interferon gamma]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases

PDB ID 1tpz

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