1hku

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[[Image:1hku.png|left|200px]]
 
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{{STRUCTURE_1hku| PDB=1hku | SCENE= }}
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==CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission==
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<StructureSection load='1hku' size='340' side='right'caption='[[1hku]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12805226}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hku OCA], [https://pdbe.org/1hku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hku RCSB], [https://www.ebi.ac.uk/pdbsum/1hku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hku ProSAT]</span></td></tr>
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[[1hku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKU OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CTBP1_RAT CTBP1_RAT] Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Functions in brown adipose tissue (BAT) differentiation.<ref>PMID:10364211</ref> <ref>PMID:7624370</ref> <ref>PMID:12805226</ref>
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<ref group="xtra">PMID:012805226</ref><ref group="xtra">PMID:012037320</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hku_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hku ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Cericola, C.]]
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[[Category: Cericola C]]
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[[Category: Corda, D.]]
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[[Category: Corda D]]
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[[Category: Luini, A.]]
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[[Category: Luini A]]
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[[Category: Massaro, A.]]
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[[Category: Massaro A]]
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[[Category: Millo, E.]]
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[[Category: Millo E]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Pesce, A.]]
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[[Category: Pesce A]]
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[[Category: Spano , S.]]
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[[Category: Spano S]]
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[[Category: Acyl-coa]]
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[[Category: Acyltransferase]]
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[[Category: Brefeldin some]]
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[[Category: Golgi membrane]]
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[[Category: Nad]]
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[[Category: Transcription co-repression]]
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[[Category: Transcription co-repressor]]
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Current revision

CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission

PDB ID 1hku

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