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1hi4

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[[Image:1hi4.png|left|200px]]
 
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{{STRUCTURE_1hi4| PDB=1hi4 | SCENE= }}
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==Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex==
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<StructureSection load='1hi4' size='340' side='right'caption='[[1hi4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===EOSINOPHIL-DERIVED NEUROTOXIN (EDN) -ADENOSINE-3'-5'-DIPHOSPHATE COMPLEX===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hi4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HI4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11154698}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hi4 OCA], [https://pdbe.org/1hi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1hi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hi4 ProSAT]</span></td></tr>
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[[1hi4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI4 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RNAS2_HUMAN RNAS2_HUMAN] This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.<ref>PMID:3458170</ref> <ref>PMID:12578357</ref>
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<ref group="xtra">PMID:011154698</ref><ref group="xtra">PMID:008759319</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/1hi4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hi4 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Large Structures]]
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[[Category: Acharya, K R.]]
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[[Category: Acharya KR]]
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[[Category: Boix, E.]]
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[[Category: Boix E]]
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[[Category: Leonidas, D D.]]
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[[Category: Leonidas DD]]
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[[Category: Minson, K.]]
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[[Category: Minson K]]
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[[Category: Prill, R.]]
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[[Category: Prill R]]
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[[Category: Suzuki, M.]]
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[[Category: Suzuki M]]
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[[Category: Swaminathan, G J.]]
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[[Category: Swaminathan GJ]]
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[[Category: Turton, R.]]
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[[Category: Turton R]]
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[[Category: Youle, R J.]]
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[[Category: Youle RJ]]
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[[Category: Hydrolase]]
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[[Category: Ribonuclease]]
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[[Category: Rnase us]]
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[[Category: Rnase-2]]
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Current revision

Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex

PDB ID 1hi4

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OCA

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