1o78

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[[Image:1o78.png|left|200px]]
 
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{{STRUCTURE_1o78| PDB=1o78 | SCENE= }}
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==Biotin carboxyl carrier domain of transcarboxylase (1.3S) [10-48] deletion mutant==
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<StructureSection load='1o78' size='340' side='right'caption='[[1o78]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1o78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O78 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o78 OCA], [https://pdbe.org/1o78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o78 RCSB], [https://www.ebi.ac.uk/pdbsum/1o78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o78 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BCCP_PROFR BCCP_PROFR] The biotinyl 1.3S subunit serves as a carboxyl carrier between the substrate-binding sites on the 12S and 5S subunits.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o78_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o78 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A deletion mutant of the transcarboxylase biotin carrier protein was completely labeled with 13C and 15N. A multitude of 2D and 3D NMR spectra were recorded and assigned. An NMR solution structure was derived from the data and compared in detail with the recently published structure of the wild-type. It is shown that deletion of 30% of the amino acids does not alter the structure of the rigid protein core.
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===BIOTIN CARBOXYL CARRIER DOMAIN OF TRANSCARBOXYLASE (1.3S) [10-48] DELETION MUTANT===
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NMR studies on the solution structure of a deletion mutant of the transcarboxylase biotin carrier subunit.,Jank MM, Sadowsky JD, Peikert C, Berger S Int J Biol Macromol. 2002 Oct 1;30(5):233-42. PMID:12297230<ref>PMID:12297230</ref>
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{{ABSTRACT_PUBMED_12297230}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1o78" style="background-color:#fffaf0;"></div>
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[[1o78]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O78 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012297230</ref><ref group="xtra">PMID:010497077</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Propionibacterium freudenreichii subsp. shermanii]]
[[Category: Propionibacterium freudenreichii subsp. shermanii]]
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[[Category: Berger, S.]]
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[[Category: Berger S]]
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[[Category: Jank, M M.]]
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[[Category: Jank MM]]
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[[Category: Peikert, C.]]
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[[Category: Peikert C]]
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[[Category: Sadowsky, J D.]]
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[[Category: Sadowsky JD]]
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[[Category: Carboxyl carrier]]
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[[Category: Carrier protein]]
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[[Category: Transcarboxylase]]
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[[Category: Transferase]]
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Current revision

Biotin carboxyl carrier domain of transcarboxylase (1.3S) [10-48] deletion mutant

PDB ID 1o78

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