4iio

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'''Unreleased structure'''
 
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The entry 4iio is ON HOLD until Paper Publication
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==Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide==
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<StructureSection load='4iio' size='340' side='right'caption='[[4iio]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4iio]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iio OCA], [https://pdbe.org/4iio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iio RCSB], [https://www.ebi.ac.uk/pdbsum/4iio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iio ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
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Authors: Dong, A., Guan, X., Huang, H., Gu, J., Tempel, W., Sidhu, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Intersectin|Intersectin]]
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Description: Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Gu J]]
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[[Category: Guan X]]
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[[Category: Huang H]]
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[[Category: Sidhu S]]
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[[Category: Tempel W]]
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[[Category: Tong Y]]

Current revision

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

PDB ID 4iio

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