1hdi

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[[Image:1hdi.gif|left|200px]]<br />
 
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<applet load="1hdi" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hdi, resolution 1.8&Aring;" />
 
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'''PIG MUSCLE 3-PHOSPHOGLYCERATE KINASE COMPLEXED WITH 3-PG AND MGADP.'''<br />
 
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==Overview==
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==Pig muscle 3-PHOSPHOGLYCERATE KINASE complexed with 3-PG and MgADP.==
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3-phosphoglycerate kinase (PGK) is a typical kinase with two structural, domains. The domains each bind one of the two substrates, 3-phosphoglycerate (3-PG) and MgATP. For the phospho-transfer reaction to, take place the substrates must be brought closer by a hinge-bending domain, closure. Open and closed structures of the enzyme with different relative, domain positions have been determined from different species, but a, comprehensive description of this conformational transition is yet to be, attained. Crystals of pig muscle PGK in complex with MgADP and, 3-phosphoglycerate were grown under the conditions which have previously, resulted in crystals of the closed, catalytically competent conformation, of Trypanosoma brucei PGK. The X-ray structure of the pig muscle ternary, complex was ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11178909 (full description)]]
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<StructureSection load='1hdi' size='340' side='right'caption='[[1hdi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hdi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HDI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hdi OCA], [https://pdbe.org/1hdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hdi RCSB], [https://www.ebi.ac.uk/pdbsum/1hdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hdi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGK1_PIG PGK1_PIG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/1hdi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hdi ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1HDI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]] with MG, AMP and 3PG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3]]. Structure known Active Sites: 3PG and AMP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HDI OCA]].
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*[[Phosphoglycerate kinase 3D structures|Phosphoglycerate kinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure., Szilagyi AN, Ghosh M, Garman E, Vas M, J Mol Biol. 2001 Feb 23;306(3):499-511. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11178909 11178909]
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[[Category: Large Structures]]
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[[Category: Phosphoglycerate kinase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Garman, E.]]
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[[Category: Garman E]]
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[[Category: Ghosh, M.]]
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[[Category: Ghosh M]]
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[[Category: Szilagyi, A.N.]]
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[[Category: Szilagyi AN]]
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[[Category: Vas, M.]]
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[[Category: Vas M]]
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[[Category: 3PG]]
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[[Category: AMP]]
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[[Category: MG]]
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[[Category: glycolysis]]
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[[Category: kinase]]
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[[Category: phosphoglycerate]]
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[[Category: ternary complex]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:34:41 2007''
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Current revision

Pig muscle 3-PHOSPHOGLYCERATE KINASE complexed with 3-PG and MgADP.

PDB ID 1hdi

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