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4is8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4is8 is ON HOLD Authors: Musille, P.M., Pathak, M.C., Ortlund, E.A. Description: A SIX-RESIDUE INSERTION IN THE HUMAN LRH-1 IS SUFFICIENT TO INDUCE...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors== | |
| + | <StructureSection load='4is8' size='340' side='right'caption='[[4is8]], [[Resolution|resolution]] 2.78Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4is8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IS8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4is8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4is8 OCA], [https://pdbe.org/4is8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4is8 RCSB], [https://www.ebi.ac.uk/pdbsum/4is8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4is8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. | ||
| - | + | ==See Also== | |
| - | + | *[[Liver receptor homolog-1|Liver receptor homolog-1]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Musille PM]] | ||
| + | [[Category: Ortlund EA]] | ||
| + | [[Category: Pathak MC]] | ||
Current revision
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors
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