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4gs0

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[[Image:4gs0.png|left|200px]]
 
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{{STRUCTURE_4gs0| PDB=4gs0 | SCENE= }}
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==Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide==
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<StructureSection load='4gs0' size='340' side='right'caption='[[4gs0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gs0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GS0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7961&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FTY:DEOXY-DIFLUOROMETHELENE-PHOSPHOTYROSINE'>FTY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gs0 OCA], [https://pdbe.org/4gs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gs0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gs0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
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===Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide===
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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{{ABSTRACT_PUBMED_23296072}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4gs0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS0 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Alicea-Velazquez, N L.]]
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[[Category: Alicea-Velazquez NL]]
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[[Category: Boggon, T J.]]
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[[Category: Boggon TJ]]
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[[Category: Jakoncic, J.]]
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[[Category: Jakoncic J]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-transferase complex]]
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[[Category: Phosphatase domain]]
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[[Category: Protein-protein complex]]
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Current revision

Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide

PDB ID 4gs0

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