This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1z1x
From Proteopedia
(Difference between revisions)
| (15 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1z1x.gif|left|200px]]<br /><applet load="1z1x" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1z1x, resolution 3.20Å" /> | ||
| - | '''Crystal Structure of a novel disintegrin from Saw-scaled viper at 3.2 A resolution'''<br /> | ||
| - | == | + | ==Crystal Structure of a novel disintegrin from Saw-scaled viper at 3.2 A resolution== |
| - | + | <StructureSection load='1z1x' size='340' side='right'caption='[[1z1x]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1z1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z1X FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1x OCA], [https://pdbe.org/1z1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z1x RCSB], [https://www.ebi.ac.uk/pdbsum/1z1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z1x ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/DID_ECHCA DID_ECHCA] Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1). |
| - | [[ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z1x_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z1x ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Disintegrin|Disintegrin]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Echis carinatus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bilgrami S]] | ||
| + | [[Category: Ethayathulla AS]] | ||
| + | [[Category: Hassan MI]] | ||
| + | [[Category: Singh B]] | ||
| + | [[Category: Singh TP]] | ||
| + | [[Category: Yadav S]] | ||
Current revision
Crystal Structure of a novel disintegrin from Saw-scaled viper at 3.2 A resolution
| |||||||||||
