4iim

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[[Image:4iim.jpg|left|200px]]
 
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{{STRUCTURE_4iim| PDB=4iim | SCENE= }}
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==Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide==
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<StructureSection load='4iim' size='340' side='right'caption='[[4iim]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4iim]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iim OCA], [https://pdbe.org/4iim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iim RCSB], [https://www.ebi.ac.uk/pdbsum/4iim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iim ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
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===Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide===
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==See Also==
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*[[Intersectin|Intersectin]]
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== References ==
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==About this Structure==
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<references/>
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[[4iim]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIM OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong, A.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Dong A]]
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[[Category: Gu, J.]]
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[[Category: Edwards AM]]
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[[Category: Guan, X.]]
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[[Category: Gu J]]
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[[Category: Huang, H.]]
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[[Category: Guan X]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Huang H]]
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[[Category: Sidhu, S.]]
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[[Category: Sidhu S]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Wernimont, A.]]
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[[Category: Wernimont A]]
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[[Category: Endocytosis]]
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[[Category: Itsn1]]
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[[Category: Protein-peptide complex]]
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[[Category: Sgc]]
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[[Category: Sh3 domain]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide

PDB ID 4iim

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