1z4u

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[[Image:1z4u.gif|left|200px]]<br /><applet load="1z4u" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1z4u, resolution 2.80&Aring;" />
 
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'''hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585'''<br />
 
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==Overview==
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==hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585==
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A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
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<StructureSection load='1z4u' size='340' side='right'caption='[[1z4u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1z4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4U FirstGlance]. <br>
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1Z4U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=PH9:'>PH9</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4U OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH9:(2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC+ACID'>PH9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4u OCA], [https://pdbe.org/1z4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4u RCSB], [https://www.ebi.ac.uk/pdbsum/1z4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4u ProSAT]</span></td></tr>
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Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15911260 15911260]
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</table>
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[[Category: Hepatitis c virus]]
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== Function ==
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[[Category: Protein complex]]
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[https://www.uniprot.org/uniprot/O93077_9HEPC O93077_9HEPC]
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[[Category: RNA-directed RNA polymerase]]
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== Evolutionary Conservation ==
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[[Category: Anstadt, R.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Finzel, B C.]]
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Check<jmol>
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[[Category: Greene, M.]]
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<jmolCheckbox>
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[[Category: Gross, R J.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4u_consurf.spt"</scriptWhenChecked>
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[[Category: Harris, M S.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Mitchell, M A.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Nugent, R.]]
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</jmolCheckbox>
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[[Category: Pfefferkorn, J A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4u ConSurf].
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[[Category: Shelly, J A.]]
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<div style="clear:both"></div>
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[[Category: Wells, P A.]]
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__TOC__
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[[Category: CL]]
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</StructureSection>
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[[Category: GOL]]
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[[Category: Hepacivirus C]]
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[[Category: PH9]]
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[[Category: Large Structures]]
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[[Category: PO4]]
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[[Category: Anstadt R]]
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[[Category: fingers]]
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[[Category: Finzel BC]]
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[[Category: hcv]]
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[[Category: Greene M]]
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[[Category: ns5b]]
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[[Category: Gross RJ]]
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[[Category: palm]]
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[[Category: Harris MS]]
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[[Category: polymerase]]
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[[Category: Mitchell MA]]
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[[Category: thumb]]
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[[Category: Nugent R]]
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[[Category: Pfefferkorn JA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:05 2008''
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[[Category: Shelly JA]]
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[[Category: Wells PA]]

Current revision

hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585

PDB ID 1z4u

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